- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Indirect Spectrophotometric Determination of Oxymetazoline Hydrochloride | ||
| Rafidain Journal of Science | ||
| Article 7, Volume 24, Issue 1, 2013, Pages 84-95 PDF (0 K) | ||
| DOI: 10.33899/rjs.2013.67503 | ||
| Authors | ||
| Nabeel S. Othman; Sahar A. Fathe | ||
| Abstract | ||
| A simple and sensitive spectrophotometric method for the quantitative determination of trace amounts of oxymetazoline hydrochloride (OMZ) was developed .The method based on the reaction of (OMZ) with Fe(III) in acidic medium.The librated Fe(II) coupled with potassium ferricyanide, the reaction needs heating for 25 minutes at 50 o C, to form Prussian blue which is more stable by adding 1ml of 1% ethylendiaminetetraacetic acid. The maximum absorption of the product was measured at 766 nm .Beer's law is obeyed in the concentration range 5-125 µg/10ml with a molar absorptivity of 5.07x104 l. mol-1.cm-1,with a relative error of +1.74 to +2.34 % and a relative standard deviation (RSD%) of the of ±1.272 to ±1.982 %.The method was applied successfully for the assay of OMZ in pharmaceutical preparation. | ||
| Keywords | ||
| Oxymetazoline hydrochloride; oxidation; reduction; spectrophotometry | ||
|
Statistics Article View: 564 PDF Download: 361 |
||