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Physicochemical characterization of clotrimazole- β-cyclodextrine inclusion complex | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 17, Issue 1, 2006, Pages 28-41 | ||
| Author | ||
| Bazigha Kadum al-Temimy | ||
| Abstract | ||
| Clotrimazole is commonly used for treatment of fungal infections. Its well known that, it has extremely low aqueous solubility. In this work, an inclusion complex of clotrimazole with β -cyclodextrin was prepared by phase-solubility technique as an attempt to enhance clotrimazole solubility in water and consequently its therapeutic effect as antifungal agent. Al-Mustansiriya J. Sci Vol. 17, No. 1, 2006 29 Results showed that,the aqueous solubility of clotrimazole was significantly increased after complexation with β-cyclodextrin and the phase-solubility diagram was AL-type and the stiochiometric ratio of the complex was 1:1. Moreover, the physicochemical properties of the complex was characterized by UV-spectrophotomertry, FTIR-spectrometry, and differential scanning calorimeter (DSC). In addition, thermodynamic parameters of the complex process Ks, ΔG°, Δ H°, and ΔS° were determined. It was found that, the apparent stability constant values decreased with increasing of temperature and the process of complexation was spontaneous, exothermic and enthalpy-driven. | ||
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