Follow-up Oxidative Stress in Pregnant Women

Y.  Mla-Alw, Farah; A. Al-Helaly, Luay; Y. Ahmad, Tareq

doi:10.33899/rjs.2011.6788

	Follow-up Oxidative Stress in Pregnant Women
Rafidain Journal of Science
Article 8, Volume 22, Issue 8, 2011, Pages 88-106 PDF (0 K)
DOI: 10.33899/rjs.2011.6788
Authors
Farah Y. Mla-Alw; Luay A. Al-Helaly; Tareq Y. Ahmad
Abstract
The research included a study of oxidative stress in healthy and hypertension pregnant women in Ninawa governorate through measuring (18) biochemical parameters. The study was carried out on (228) women (age 14 – 40 year). The normal pregnant women (186) divided into four groups (depending on weeks gestation 1-40 weeks) and (42) pregnant women complicated by hypertension at last period (31-40 weeks). Non pregnant women (29) were included in the study as control with similar age. The group of normal pregnant women showed significant decrease concentrations of vitamin C, vitamin E, folic acid, glutathione, uric acid, total bilirubin, zinc and iron, compared to the non-pregnant women. While there was a significant increase of : ceruloplasmin, peroxynitrite, malondialdehyde, and the activity of glutathione S-transferase. The research also included a study of the effect of gestation period on the biochemical parameters for normal pregnancy. The results showed significant decrease with increase of gestation period of vitamin C, vitamin E, folic acid, glucose, albumin, iron, calcium and glutathione while there was significant increase of malondialdehyde, copper ceruloplasmin, and glutathione S-transferrase. The results also showed that the level of oxidative stress waere high in the last gestation period (31-40 week). Moreover, the study showed the effect of the number of children on some biochemical parameters for normal pregnancy at last gestation period. The results reveald that there were direct correlation between the number of children and the concentrations of peroxynitrite and inverse correlation with the concentrations of calcium and the activity of superoxide dismutase. On the other hand, the group of women pregnant which have complication with hypertension had significant decrease concentrations of vitamin C, vitamin E, folic acid, glutathione, zinc and the activity of superoxide dismutase, and significant increase in the concentrations of uric acid, copper, peroxynitrite and in the activity of glutathione S-transferase compared to normal pregnant women
Keywords
oxidative stress; Pregnancy; Ninawa; Antioxidants; Oxidants; Hypertension

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