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A triple translocation in childhood acute lymphoblastic Leukemia | ||
| Journal Of Wassit For Science & Medicine | ||
| Article 1, Volume 6, Issue 1, 2013, Pages 38-44 | ||
| Author | ||
| ZAFIR HASSAN GHALI | ||
| Abstract | ||
| Chromosomal abnormality in childhood acute lymphoblastic leukemia( ALL) has an important role in diagnosis ,management and prognosis. Fluorescence in situ hybridization(FISH) analysis using BAC probes was performed to detect a novel translocation in childhood ALL. The BAC probe RP11-111312 revealed a triple translocation involving chromosome 9,22 and 3.This BAC probe showed signals on normal chromosome 22 and derivative chromosome 3. RP11-465M18 showing only one signal on normal chromosome 9. This study confirms the triple translocation comprising chromosome 9,22,3 as a novel chromosomal abnormality in childhood ALL. | ||
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