Effect of oxidative stress induced by iron overload in Rabbits on some biochemical parameters

	Effect of oxidative stress induced by iron overload in Rabbits on some biochemical parameters
journal of kerbala university
Article 1, Volume 6, Issue 4, 2010, Pages 331-341 PDF (0 K)
Abstract
The present study was aimed of studying the effect of oxidative stress induced by iron overload on locale male rabbits and the role of vitamin E against stress, the study was carried out at the department of biology, college of education, and university of Karbala. Fifteen adult male of rabbits were divided into three equal groups (5/groups).the first group was injected with 0.5 ml normal saline and served as a control group T1.Rabbits in the second group were injected intramuscular with 15 mg/kg Iron dextran three times a week for nine weeks T2 ,While animals in the third group were injected with 15 mg/kg Iron dextran intramuscular three times a week and orally Vitamin E (20mg/kg) for nine weeks ,Fasting blood samples are collected each three weeks for measuring the following biochemical parameters : Red blood corpuscles RBC, Packed cell volume PCV, Hemoglobin Hb, Free iron, Total iron banding capacity TIBC, Transferrin % . The result revealed that, injection with 15 mg/kg Iron dextran for nine weeks caused a significant decrease p<0.05 in RBC, PCV, Hb, and a significant increase p<0.05 in Free iron, TIBC, Transferrin %. The result revealed that, injection with 15 mg/kg Iron dextran and intubation orally 20mg/kg vitamin E for nine weeks caused significant increase (p<0.05) in serum Free iron, Transferrin %, TIBC. While non significant difference in RBC, PCV, Hb, was found in Compared with control group. The goal of this study is to find the effect of oxidative stress induced by iron overload in male rabbits and the role of vitamin E in reducing some affect of iron.

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