- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Synthesis of Novel [1,2,4]Triazolo[1,5-a]Pyridines via concerted reactions between 2‾-cinnamoyl-2-cyanoacetohydrazide and α-cyanocinamonitriles | ||
| journal of kerbala university | ||
| Article 1, Volume 6, Issue 4, 2010, Pages 55-75 PDF (0 K) | ||
| Author | ||
| Ali Hadi | ||
| Abstract | ||
| A novel one step synthesis of derivatives [1,2,4]triazolo[1,5-a]pyridines (6) from 2′-cinnamoyl-2-cyanoacetohydrazide (3) and α-cyanocinnamonitriles (2) is described. The reaction takes place by 6-exo-dig cyclization followed by an 5-exo-trig process to afford salts 6. Compound 7 were solated from the reaction mixture as the corresponding piperidinium salts due to the high stability of the heterocyclic anion. Acidification with dilute hydrochloric acid yielded the neutral [1,2,4]triazolo [1,5-a]pyridines. Now, an alternative 7-endo trig cyclization can take place and, in addition to the [1,2,4]triazolo[1,5-a] pyridines 6, the novel heterocyclic compound of seven membered ring are obtained | ||
|
Statistics Article View: 155 PDF Download: 92 |
||