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Synthesis of New 4-Aminoantipyrine derivatives | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 8, Issue 2, 2005, Pages 1-6 | ||
| Authors | ||
| Redha I. H. Al-Bayati; Suad J. Lafta; Mohammed Z. AL- Saedi | ||
| Abstract | ||
| Refluxing of 4-aminoantipyrine with propargyl chloride or p-chloro propinyl chloride in the presence of triethylainine gave the 4-(arnino-2-propinyl) antipyrine (2) or 4-[(aminopropinyl)-3-chloro)] antipyrine (3) respectively in good yield. When compound (2) was refluxed with secondary amines and paraformaldehyde in the presence of cuprous chloride, the corresponding Mannich Bases (4-10) were achieved, while the reaction of compound (3) with secondary amines in boiling ethanol gave the 4-(amino propinyl-3-alkyl/ary! amino) antipyrine (11-16) in quantitative yields. The intended compounds were identified by their IR, UV spectra and CRN. analyses data. | ||
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