- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Synthesis of Novel AminothiadiazolylCephalosporins | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 8, Issue 2, 2005, Pages 22-26 | ||
| Author | ||
| Shakir M. Alwan | ||
| Abstract | ||
| tnino-thiadiazolyl cephalosporins were designed, synthesized and their structures were characterized by spectral and elemental analysis. These cephalosporins included derivatives 7-amino cephalosporanic acid ,acylated at the C7-amino group.The acyl side chain contained 2-amino 5-mercapto-l,3,4,thiadiazole cross-linked with benzaldchyde or p-chlorobenzaldehvdc through a Schiffs base. The Cephalosprin nuleus was linked with these Schiffs bases through a sulfide linkage using chloroacetic acid as a spacer arm, or through a disulfide bond using mercaptoacetic acid as a spacer arm. These aminothiadiazoyl-Ccph alosporins were characterized using spectral and elemental analysis. A preliminary antimicrobial assay for these novel aminothiadiazolyl-cephalosporins was achieved using representative strains of G(+) and G(-) bacteria and Candida Albicans. The prepared cephalosporins showed reasonable antimicrobial potency when compared with Cephalexin. | ||
|
Statistics Article View: 109 PDF Download: 58 |
||