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Synthesis of Novel Cinnoline Derivatives | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 17, Issue 4, 2006, Pages 38-47 | ||
| Author | ||
| Olfa A. AL-Janaby | ||
| Abstract | ||
| Refluxing 5-methyl-4-chloro cinnoline with ethyl p-amino benzoate in boiling ethanol for 12 hrs lead to the formation of 5-methoxy-4(ethyl-p-amino benzoate) cinnoline [1] with good yield. On treatment of compound [1] with hydrazine (99%), hydrazide derivative [2] was obtained. This hydrazide was treated with phenyl isothiocyanate on refluxing in boiling ethanol for 4 hrs, gave thiosemicarbazide derivative [3], which have been treated with conc. KOH or H2SO4 afford thiadiazole [4] and triazole [5] respectively. The synthesized compounds have been elucidated using some spectral data (IR and UV) and C.H.N. analyses. We have been stimulated to test the antimicrobial activity of cinnoline derivatives on three species of pathogenic microorganisms (Eschericha coli, Staphylococcus,Psendomonus). | ||
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