M. Al-Kuraishy, H. (2012). Desmopressin Acetate Effects on Human Vigilance Task and Psychomotor Performances in Normal Healthy Volunteers: Randomized Single Blind Clinical Trail. , 25(3), 191-195.
Hayder M. Al-Kuraishy. "Desmopressin Acetate Effects on Human Vigilance Task and Psychomotor Performances in Normal Healthy Volunteers: Randomized Single Blind Clinical Trail". , 25, 3, 2012, 191-195.
M. Al-Kuraishy, H. (2012). 'Desmopressin Acetate Effects on Human Vigilance Task and Psychomotor Performances in Normal Healthy Volunteers: Randomized Single Blind Clinical Trail', , 25(3), pp. 191-195.
M. Al-Kuraishy, H. Desmopressin Acetate Effects on Human Vigilance Task and Psychomotor Performances in Normal Healthy Volunteers: Randomized Single Blind Clinical Trail. , 2012; 25(3): 191-195.

Desmopressin Acetate Effects on Human Vigilance Task and Psychomotor Performances in Normal Healthy Volunteers: Randomized Single Blind Clinical Trail

IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 25, Issue 3, 2012, Pages 191-195
Author
Hayder M. Al-Kuraishy
Abstract
Abstract
Background: Desmopressin is a synthetic form of human vasopressin hormone act chiefly on V2 receptor that found in vascular and brain tissues ;and it's primarily used for treatment of nocturnal enuresis .Also previous studies in animals suggested that central vasopressinergic system proceed on cognitive function .
Aim of study: This study aimed to estimate the central effects of desmopressin on human vigilance task and psychomotor performances in normal healthy volunteers.
Subjects and method : This study done in the course of measurement of recognition reaction time (RRT); movement reaction time (MRT),total reaction time(TRT) and flickering-fusion frequency threshold which reflects the vigilance task and psychomotor performances by specific Leeds Battery Instrument before and after single trans-nasal desmopressin acetate in 20 healthy volunteers(17 males+3 females).
Results: This study showed that desmopressin produced significant effects on all vigilance- psychomotor performance parameters (P<0.05) with the exception of on critical flickering which produced insignificant effects ( P >0.05).
Conclusion: Desmopressin acetate significantly improves human vigilance- psychomotor performances and improves cognitive function so we recommend using this drug for nootropic effects and stimulation of mental function.
Keywords
desmopressin; psychomotor performance and critical flickering
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