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Serum Uric Acid Concentration in Patients with Polycystic Ovary Syndrome Treated by Metformin | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 25, Issue 3, 2012, Pages 205-209 | ||
| Authors | ||
| Wahda B. Al-Youzbaki; Rabie Gabriel Abdullah; Ahmed J. Al-Hussaini | ||
| Abstract | ||
| Background: Serum uric acid levels have emerged as a cardiovascular risk factor, and interventions aimed to decrease its level have been related with an improvement in clinical and non-clinical cardiovascular outcomes. This is particularly strong among persons at high cardiovascular risk, including those with hypertension, diabetes or polycystic ovary syndrome (PCOS). The studies about the effect of metformin on serum uric acid in patients with PCOS are very scarce at least in our locality. Objective: To evaluate the effect of metformin on serum uric acid concentration as non-classical cardiovascular risk factor in patients with PCOS in Mosul City in Iraq. Design: Case control study, Study Period: From 1st of November 2010 and 1st April 2011. Patients & Methods: A group of 40 women with PCOS of reproductive age who used metformin for more than three months (metformin users), with another age- and body mass index (BMI)-matched group of 52 women with PCOS who did not use metformin (metformin non-users), were included in this study. From each patient, a 5 ml blood sample was taken. The serum was used to measure the S.UA level using commercially available kit. BMI calculated as weight in kilograms divided by the squared height in meters. Results: This study revealed a significant lower levels of serum uric acid (P = 0.045) in metformin users as compared with metformin non-users and the serum uric acid levels were significantly correlated with BMI (r = 0.326, P = 0.001), systolic blood pressure (SBP) (r = 0.283, P = 0.006) and diastolic blood pressure (DBP) (r = 0.301, P = 0.003) when the whole study population was taken. Conclusion: Metformin therapy for more than three months in patients with PCOS is associated with significantly lower levels of serum uric acid and these levels are significantly related to BMI, SBP, and DBP. | ||
| Keywords | ||
| polycystic ovary syndrome; metformin; Uric acid | ||
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