Clinical effectiveness of subgingival application of 25%metronidazole gel as a monotherapy & as adjunctive treatment of chronic periodontitis

M.Sc,; Maha Abdul Aziz. B.D.S, Dr.

	Clinical effectiveness of subgingival application of 25%metronidazole gel as a monotherapy & as adjunctive treatment of chronic periodontitis
MUSTANSIRIA DENTAL JOURNAL
Article 1, Volume 9, Issue 2, 2012, Pages 245-251
Authors
; Dr. Maha Abdul Aziz. B.D.S
Abstract
Metronidazole has been used successfully as an adjunctive antimicrobial drug in the treatment of periodontal diseases. The aim of this study was to determine if two subgingival applications of 25% metronidazole (MET) gel of one week interval alone or adjunct to root planing (RP) have a significant effect on the following periodontal parameters: plaque index (PLI), bleeding on probing (BOP), Probing pocket depth (PPD), relative attachment level (RAL). A metronidazole 25 % dental gel has been developed for application locally into the periodontal pocket, the gel disintegrates in the periodontal pocket and releases metronidazole. A total of 20 patients with an age range of (30-40) yr, each patient with at least 4 sites with PPD ≥ 4mm and clinical attachment loss (1-2) mm participated in this study. The study protocol included a pretreatment phase of plaque control instructions followed by scaling and polishing until the oral hygiene status reached to mean PLI (0.4).An alginate impression was taken and an occlusal stent was constructed for each patient to measure the relative attachment level. A total of 270 sites were randomly assigned to receive either 25% MET gel alone (group 1) or root planing plus 25% MET gel (group 2). Clinical periodontal parameters which include: PLI, BOP, PPD and RAL were recorded at day zero, after 2 weeks, 4 weeks, 6 weeks and 8 weeks. Statistical analysis of data of the two groups revealed significant improvements in all periodontal parameters (PPD, RAL, BOP) at all subsequent visits when compared with the base line, the same result was demonstrated when the two groups were compared with each other at week 8 except (group 1) which did not show a significant gain in RAL at week 2 only. Mean plaque scores were improved in the two groups at all visits and non significant differences were demonstrated when the two groups were compared with the baseline and at week 8. In conclusion, double applications of 25% MET gel subgingivally have a positive effect on reducing the clinical signs of periodontal disease.
Keywords
KEYWORDS; metronidazole gel

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