Synthesis And Biological Activity Of Some New Compounds Containing 1,2,4-Triazole And Their Derivatives

	Synthesis And Biological Activity Of Some New Compounds Containing 1,2,4-Triazole And Their Derivatives
journal of kerbala university
Article 1, Volume 5, Issue 4, 2009, Pages 58-69 PDF (0 K)
Abstract
Condensation of 1,2- dibromo ethane with para hydroxy benzoic acid gave 1,2-Ethane-bis-4-oxybenzoic [1]. This Compound was converted with the thionyl chloride to give 1,2-Ethane-bis-4-oxybenzoyl chloride [2]. Reaction of compound [2] with thiosemicarbizades gave 1,2-Ethane-bis[4-oxybenzoyl-thiosemicarbazide] [3] and opteined 1,2-Ethane-bis[3-mercapto-5-phenoxy-1,2,4-triazole] [4] from treatment compound [3] with NaOH (4%) .The new compounds 1,2-Ethane-bis[3-(substituted thioacyl)-4-(substituted acyl)-5 phenoxy-1,2,4-triazole] [5a-d] and 1,2-Ethane-bis[3-(substituted alkylthio)-5 phenoxy-1,2,4-trizole] [5e-f] derived from compound [4] were synthesized and characterized by physical and spectral data. All the compounds [4], [5a-d] and [5e-f] have been screened for antibacterial activity against Escherichia coli (G-) and Enterobacter (G-). Most of compounds were found to be active antibacterial

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