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In vivo immunohistochemical investegation of bone deposition at collagen coated Ti implant surface | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 23, Issue 0, 2011, Pages 47-52 | ||
| Authors | ||
| Ban A. Al-Ghani; Athraa Y.Al-Hijazi; Thair L.AL-Zubaydi Thair L.AL-Zubaydi | ||
| Abstract | ||
| Background: Dental implants provide a unique treatment modality for the replacement of lost dentition. Functional surface modifications by organic material such as collagen coating seem to enhance early peri-implant bone formation, enhancing the initial cell attachment. The aim of the study was to study the expression of osteocalcin and growth hormone receptor as bone formation markers in collagen coated and uncoated implant in interval periods(2,and 6 weeks). Materials and Methods: Commercially pure Titanium(cpTi) implants, coated with collagen protein, were placed in the tibias of 32 New Zealand white rabbits, immunohistochemical tests for detection of expression of osteocalcin and growth hormone receptor were performed on all the implants of both control and experimental groups for (2, and 6 weeks) healing intervals. Mechanical test (torque removal test) was performed as an indicator for the presence of osseointegration and as a test for the mechanical property of bone-implant interface, because the torsion appears to be primarily probing the interface mechanics. Results: Removal torque mean values in all studied groups (uncoated and coated with collagen at two and six healing intervals were increasing with advancing time (higher at 6 than 2 weeks periods). And coated implant showed high value in comparison to control. Results have shown that positive reaction for OC&GHR was expressed by osteoblast cells (OB)at implants coated with collagen ,indicating that bone formation &maturation was accelerated by adding biological materials as a modification modality of implant surface.. Conclusion: Immunohistochemical findings revealed high positive expression range from strong to moderate of osteocalcin and GHR in coated implant in comparison to uncoated specialy in early periods. | ||
| Keywords | ||
| Collagen; dental implant; biochemical bone markers; osteocalcin; growth hormone receptor | ||
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