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Efficacy of topical flax paint for the treatment of recurrent aphthous stomatitis | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 23, Issue 0, 2011, Pages 100-107 | ||
| Authors | ||
| Tagreed Altaei; Shaheen A. Ahmed; Ahmed A. Haider | ||
| Abstract | ||
| Background: Recurrent aphthous stomatitis is commonly observed and is mediated by the immune system. Lesions appear as painful, tiny, discrete vesicles. Flax (Linum usitatissimum) has antiseptic, anti-inflammatory properties. The present study was a randomized, double-blinded, placebo controlled conducted to assess the efficacy of Flax paint in this disease. Methods: Dermal irritation study; was performed by primary irritation to the skin and measured by a patch-test technique on the intact skin of the albino rabbit. Clinical study; 64 RAS patients, randomized to receive Flax paint or placebo topically (three times a day, for five days). The efficacy of the treatment was estimated (healing time, ulcer size reduction, pain score, change in condition), β-2 microglobulin (β-2M), α-1Antitrypsin (α-1AT), CRP & ESR, Safety, tolerance, side effects were assessed. Results: Dermal irritation test in vivo showed no sign of irritation in Flax paint. Clinical study; four days after treatment, 95% of Flax group were completely healed from aphthous ulcers, compared with placebo group ( p < 0.0001). Flax paint group showed significant pain reduction after the 1st or 2nd dose application compared to baseline and placebo. Serum β-2M, α-1AT, CRP, & ESR values showed significant reduction in Flax paint treated group compared to baseline and placebo. No sign of adverse effects or tolerance. Conclusion: This is the first time reporting that Flax paint reduced the time to repair mucosal tissue (ulcer healing), and pain persistence, it has anti-inflammatory, and analgesic effect. There was no evidence of any adverse effects | ||
| Keywords | ||
| Flax; recurrent aphthous stomatitis | ||
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