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In vivo study of the effect of collagen protein coated implant as compared with implants coated with a mixture of partially stabilized zirconia and collagen on osseointegration | ||
| Journal of baghdad college of dentistry | ||
| Article 1, Volume 23, Issue 0, 2011, Pages 108-116 | ||
| Authors | ||
| Thair L .AL-Zubaydi; Athraa Y. Al-Hijazi; Ban A. Al-Ghani | ||
| Abstract | ||
| Background: Biocompatibility of orthopaedic surgical implants with bone tissue allows adequate osseointegration between the bone and implant. To achieve this, implants are coated with biocompatible materials Commercially pure titanium is widely used as dental implant material because of its suitable mechanical properties and excellent biocompatibility,and to enhance osseointegration of the implant,organic and inorganic materials are used as a bioinert coating material. Aim of the study: Comparison of the influence of the implant coated by biological material(collagen),and implant coated by both bioinert ceramic(zirconia) and( collagen), on osseointegration by immunohistochemical , and radiographical studies with mechanical test. Materials and Methods: Commercially pure Titanium(cpTi) implants, coated with PSZ powder by electrophoretic deposition (EPD) method, collagen protein, and mixture of collagen and partially stabilized zirconia(PSZ) were placed in the tibias of( 12 )New Zealand white rabbits, immunohistochemical tests for detection of expression of osteocalcin and growth hormone receptor were performed on all the implants of both control and experimental groups for(3days,1, 2and6weeks) healing intervals.Mechanical test (torque removal test) was performed as an indicator for the presence of osseointegration and as a test for the mechanical property of bone-implant interface. Results: have illustrated that removal torque mean values, in all studied groups (uncoated and coated with both PSZ and collagen at (2&6weeks) healing intervals were increasing with advancing time (higher at 6 than other periods),also results have shown that positive reaction for osteocalcin(OC)& growth hormone receptoe(GHR) was expressed by osteoblast cells(OB)at implants coated with collagen and implants coated with zirconia and collagen,indicating that bone formation &maturation was accelerated by adding biological materials as a modification modality of implant surface.. Conclusion: It is concluded that coating of implant with collagen and coating with both PSZand collagen showed an increment in osseointegration in short interval period. | ||
| Keywords | ||
| dental implant; Collagen; Zirconia; Biochemical; electrophoretic deposition bone markers; osteocalcin; growth hormone receptor | ||
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