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Synthesis and characterization of new heterocyclic compounds with studying its biological activity | ||
| karbala journal of pharmaceutical sciences | ||
| Article 1, Volume 4, Issue 4, 2013, Pages 119-135 PDF (0 K) | ||
| Authors | ||
| ; Ibtisam K.Jassim; Malak N.Safi | ||
| Abstract | ||
| Reaction of malonic acid di hydrazide (1) with CS2 / KOH then with hydrazine hydrate gave 1,2,4-triazole (2) which was reacted with different substituted benzaldehyde to give Schiff bases derivatives (3-8) respectively. Schiff bases (3-8) were reacted with thioglycolic acid to give thiazolidenones (9-13). Also ,Schiff bases were reacted with glycine to give imidazolidenone (14-18). The prepared compounds were characterized by FT-IR ,1H-NMR ,Uv/vis spectra ,melting points were recorded and the purity was checked through T.L.C.technique. Some of the synthesized compounds were screened for antibacterial activity | ||
| Keywords | ||
| Triazoles; imidazoles; thiazolidine | ||
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