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Indirect Spectrophotometric Assay of Hydroxyurea with its Pharmaceutical Application as Capsules | ||
| Rafidain Journal of Science | ||
| Article 6, Volume 24, Issue 3, 2013, Pages 53-64 PDF (0 K) | ||
| DOI: 10.33899/rjs.2013.71259 | ||
| Authors | ||
| Wadala A. Bashir; Zainab W. Majid | ||
| Abstract | ||
| The oxidation–reduction reaction between hydroxyurea and ferric ions has been utilised for spectrophotometric assay of hydroxyurea. The ferrous ions that are produced from the redox reaction were complexed with 2,2´-bipyridyl reagent to form a pink-red tris-chelate which has an absorption maxima at 522 nm. Beer's law agreed with the range of 5-150 μg of hydroxyurea per 20 ml, i.e., 0.25-7.5 ppm, with a corresponding average molar absorptivity of 1.65x104 l.mol-1. cm-1, Sandell sensitivity index is 0.0044 μg.cm-2, limit of detection 0.01μg.ml-1 and limit of quantitation of 0.03 μg.ml-1. The present method has been applied successfully to the determination of hydroxyurea in its pharmaceutical preparation as capsule. | ||
| Keywords | ||
| Hydroxyurea; bipyridyl; spectrophotometry | ||
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