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The effect of Sildenafil on endometrial characters in patients with infertility | ||
| Medical Journal of Tikrit | ||
| Article 1, Volume 18, Issue 182, 2012, Pages 330-338 | ||
| Authors | ||
| Zainab Laaiby; Sajeda A. Al-Rubaye; Ali F. Al-Assadi | ||
| Abstract | ||
| Objective: To study the role of sildenafil on the echogenic pattern of endometrium in infertile patients with bad endometrium. Setting: Infertility center in Basrah Maternity and Children hospital. Design: Case control prospective study. Methodology: 28 patients had primary or secondary infertility with mature Graffian follicle and bad endometrial thickness (control group) in the previous cycle . The same patients were considered as study group in the present cycle after giving them sildenafil citrate (Erasma) (Mepha company) 25 mg vaginally every 6 hours for 5 days from day 8th of the cycle and those patients were reevaluated by TVS (7.5 MHZ) at day 8th and 13 th of cycle for endometrial thickness and pattern with number and size of Graffian follicle. Result : A total of 28 infertile women were included in this study. The control group had a mean of endometrial thickness of 5.21+2.8 mm at time of ovulation. There was statistically significant increase in the endometrial thickness from day 8th to day 13th in study group as compared to that of the same patients in control group and the difference is highly significant. Vaginal sildenafil increase endometrial thickness to >7mm in about 35.7% of patients in the study group without any side effect. 71.4% of patients in study group had hyperechogenic endometrium which was higher than those in the control group but the difference is statistically not significant and the percentage for those with isoechogenic is higher in control group compared to the study group. Conclusion: Vaginal sildenafil was significantly effective in improving endometrial thickness in patients receiving ovulation induction therapy with bad endometrial thickness in previous cycle. It causes no systemic side effect. | ||
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