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Synthesis and Characterization of New Compounds Derived from (1,3-Oxazol-5-(4H)-one and Study Their Effect on ALP Activity | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 23, Issue 5, 2012, Pages 129-138 | ||
| Author | ||
| Nagham M. Al-Janabi | ||
| Abstract | ||
| Synthesis of new derivatives compound of 1,3-oxazol-5(4H)-one) (3) by cyclization of (Glycin) with nicotinoyl chloride, reacting compound (3) with hydrazine hydrate 99% to give the imidazole derivative (4), when treating compound (4) with a, b and c different aldyhades to form Schiff bases compound (5a-c). Schiff bases converted into heterocyclic compound by reacting it with benzoyl chloride to give derivatives of compound (6a-c). Reacting thiourea with compounds (6a-c) will give derivatives of compound (7a-c), the last reaction of compounds are cyclized with diethyl malonat giving the derivatives of compound (8). Also, the biochemical study has been done to show the effect of these derivatives on the chosen enzyme total ALP. It was found that all these compound have inhibitory effect at both concentration (10-2, 10-4)M and observed that (10-4 M) does not have any inhibition or activation on enzyme activity. | ||
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