Effect of Pimpinella anisum and Foeniculum vulgare Seeds Extracts in Protect From Oxidative Stress Induced By Hydrogen Peroxide in Swiss Albino Mice

	Effect of Pimpinella anisum and Foeniculum vulgare Seeds Extracts in Protect From Oxidative Stress Induced By Hydrogen Peroxide in Swiss Albino Mice
Tikrit Journal of Pure Science
Article 1, Volume 17, Issue 3, 2012, Pages 60-66
Abstract
This study was conducted the effect of two plants : Foeniculum vulgare and piminella anisum as antioxidant from oxidative stress after treated with 0.5% hydrogen peroxide (H2O2) in swiss albino mice with (3) months age . mice were divided in to four groups (12 mice / group ). The mice were given drinking water containing the two plants above (750 mg / gm body weight). All groups were treated daily for aperiod of (30) days for each plant . The parameters had been depending include lipoproteins and activity of Glutathion-s-transferase and peroxidase as markers for oxidative injury .The results showed the treatment with H2O2 (0.5%) causes asignificant increase p≤0.05) in total cholesterol (TC) and triglycerides (TG) , and significant decrease (p≤ 0.05) in high density lipoprotein (HDL-C) , Low density Lipoprotein (LDL-C) , very low density lipoprotein (VLDL-C) and Atherogenic index in male and female . Treatment with Foeniculum Vulgare and Piminella anisum showed significant increase (p≤0.05) in all parameters (types of lipoproteins ) in male and female comparing to the control and group treatment with H2O2 The result showed significant decreas (p≤0.05) in glutathion-s- transferase in mice (male and female ) were treated with H2O2 , while the treatment with Foeniculum Vulgare lead to significant decrease in enzyme activity , but the treatment with pimpinella anisum lead to significant increase in enzyme activity in female only and significant increase (p≤0.05) in peroxidase activity for all treatment that employed in male and female comparision to control .

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