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Histological Changes on The Liver of The Mothers Treated with Uranyl Acetate in Albino Rats. | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 17, Issue 4, 2012, Pages 49-54 | ||
| Authors | ||
| Nusaibah Amer; Sabah N. Alwachi | ||
| Abstract | ||
| This study was carried out to investigate the toxicity of the oral administration of uranyl acetate on some activity organs. For this purpose, twenty females mature Albino rats which were divided into four equal groups, control group administrated distilled water, and other three groups administrated orally by (50, 75 and 100 mg/kg/b.w. /day of uranyl acetate). The route of administration was oral intubations for 70 days (10 weeks), for 10 days before mating with untreated males, as well as during pregnancy (3 weeks) and lactation (5 weeks). liver were taken from mothers of rats. Results of histopathological changes to the liver of rat mothers showed congestion to the central vein, congestion to the sinusoid capillaries, and swelling of the hepatocytes. Vacuolation of the cytoplasm of the hepatocytes, and necrosis to the hepatocytes, also slight hyperplasia to kupffer cells and, Lipid vacuolation in the cytoplasm. | ||
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