Prophylactic effect for the sesame oil and camphor oil on the infected burn skin of mice

Q. Majeed, Raghad

	Prophylactic effect for the sesame oil and camphor oil on the infected burn skin of mice
Tikrit Journal of Pure Science
Article 1, Volume 17, Issue 4, 2012, Pages 26-33
Author
Raghad Q. Majeed
Abstract
The effect of sesame oil and camphor oil on experimental burn mice infected with common pathogen Pseudomonas aeruginosa was studied . Sesame oil and camphor oil which prepared in Vaseline gel at two concentration (2.5% , 5%) and, and Gentamycin cream 3% were used .The macroscopic changing on the skin were demonstrated, the result shown that treated animal with oils were improved while the animal treated with Gentamycin cream showed no healing for the skin . The histological study of infected skin showed severe necrosis and neutrophil infiltration in the epidermis and dermis and the inflammatory reaction extended to hypodermis is reflected by fibrin deposition and neutrophil infiltration also granulation tissue started in to the subcutaneous tissue ,The oils were effect on treated skin after one week and complete the healing after 3week from the beginning of treatment and there was no response for the animal treated with Gentamycin cream till end of treatment duration . Combination of sesame oil 2.5%and Gentamycin cream in equal percent used in treatment the infected burn skin and compare with Moist exposed burn ointment (MEBO) the influence was more effective than using oil or cream alone the animals were healing through 2 weeks after using the combination oil and Gentamycin , and MEBO ointment. There was no histo-pathological lesions for skin of animal healing from the burn area of it covered with thick layer of epithelial cell and replaced with thin layer of epithelial cell .

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