Study of The changes in Sexual hormones levels and a number of immune parameters of Women with Brest Cancer and Ovary Cancer

Jasim Mohammed AL-Humesh, Mousa

	Study of The changes in Sexual hormones levels and a number of immune parameters of Women with Brest Cancer and Ovary Cancer
Tikrit Journal of Pure Science
Article 1, Volume 18, Issue 1, 2013, Pages 95-102
Author
Mousa Jasim Mohammed AL-Humesh
Abstract
This research has been applid on (122) blood taken from women with breast cancer and ovary cancer . Those Patient women are frequent patients from state hospitals and from out –patient clinics in Salah-AL-Deen and Kirkuk governments in average of (76) Samples of breast cancer and (46) Samples of Ovary cancer dating from 1/7/2010 to 1/2/2012. The Samples have been divided in the above two groups depending on the kind of therapy ,in to three sub-groups : the sub-group of patient who did not submit to therapy ,the sub-group of patient who submitted to chemical therapy ,the sub-group of patients who submitted to radiation therapy . Then the results were compared with (25) blood samples of intact women as a control group. The Sexual hormones levels such as , Estrogen ,Progesterone,FSH,LH, Activin A,Inhibin A ) has been estimated. Besides, The levels of three amino globulins have been also estimated (IgA,IgM,IgG) as well as ,the levels of interleukins have been estimated (IL-2,IL-4,IL-6,IL-8,IL10). The results showed an increase in the hormones of estrogen, progesterone ,FSH,Activin A levels in all groups as compared to the control group.More over ;the hormone level of LH has lowered in both groups of chemical and radiation therapy as compared to controle group . As for Inhibin A hormone ,there were no slight differences noticed among the sub-groups as compared to control group,but its level has lowered before therapy . The levels of IgA have increased in all sub-groups as compared to control group, while the levels of IgM have lowered in all sub-groups as compared with control group except the sub-group of Ovary cancer which was submitted to chemical and radiation therapy . As for IgG , there were no slight differences noticed among the sub-groups which were submitting to both chemical and radiation therapy as compared with control group. While the IgG levels have risen in all sub-groups before therapy . All the levels of the examined interleukins (IL-2 ,IL-4 ,IL-6 ,IL-8 ,IL-10) have increased in all the sub-groups as compared to control group.

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