Effect of effective microorganisms (EM) On Renal Function in Normal and alloxan induced  diabetic Male Rats.

J. Mohammed, Wadah; J.M .AL-Humesh, Mousa; M.Rahim, Salh

	Effect of effective microorganisms (EM) On Renal Function in Normal and alloxan induced diabetic Male Rats.
Tikrit Journal of Pure Science
Article 1, Volume 18, Issue 1, 2013, Pages 56-63
Authors
Wadah J. Mohammed; Mousa J.M .AL-Humesh; Salh M.Rahim
Abstract
This study was designed to examine the effect of Effective Microorganisms (EM) in the concentration of glucose, total protein , urea and creatinine, in normal and alloxan-induced diabetic rats. The effect of the EM in hyperglycemia and histotoxicity in kidney of male rats and these results were compared with the effect of Glibenclamide as control chemical drug. The results of this study showed that diabetes mellitus induced by alloxan for 30 days caused a significant increase in concentration of serum glucose, urea and creatinine concentration. While significantly decreased total proteins. The results of this study reveled that administration of EM produced asignificant decreased in glucose, urea and creatinine concentration. While significantly increased total proteins concentration of alloxan-induced diabetic rats. Also the results referred that the effect of EM was best the effect of the control chemical drug glibenclamide in its activity. The histological results referred that there were no clear and recognizable changes in the normal rat males treated and or not treated with EM in kidney while in the abnormal treated animals the kidney showed recognizable tissue changes which were caused by the increasing of the blood glucose while in the untreated abnormal animals the tissue changes were less. The results obtained suggest that these EM may being used for the treatments of diabetes mellitus after be sure that there is no side effect.
Keywords
Glibenclamid

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