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Synthesis , Identification and study of biological activity for some new derivatives of 1,3-oxazepene ring containing pyridine moiety | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 18, Issue 1, 2013, Pages 169-176 | ||
| Author | ||
| Shaymaa H.A | ||
| Abstract | ||
| This search includes preparation of some isoniazid hydrazones with different substituents (II1-4) from the reaction between isoniazid and aromatic benzaldehyde with out using a solvent under thermal fussion and microwave .Compounds of 1,3-oxazepen 4,7-Dione (III5-8) have also been prepared by ring closer reaction through the treatment of the prepared hydrazones (II1-4) and phthalic anhydride , yields of products and physical spectroscopic changes have been tested specially using infrared and ultra violet spectra . The compounds (III8,III7,III6,III5,II4,II3,II2,II1) have been tested on four types of germs which cause illness and resist the biotic agents and these germs (Escherichia coli) and (pseudomonas auruginosa) as negative gram stain and (streptococcus pyogene) and (staphylococcus aureus) as positive garm stain. | ||
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