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Comparative Study for determination of Metoclopramide Hydrochloride Drug by Selective Electrodes and Spectrophotometric methods. | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 18, Issue 1, 2013, Pages 149-161 | ||
| Authors | ||
| Ali Ibraheem Khaleel; Suham T. Amine; Sfoog Hamad Salih | ||
| Abstract | ||
| This study includes the determination of Metoclopramide Hydrochloride (METO) drug by Selective Electrodes and spectrophotometric methods. Selective Electrodes Method: These methods include construction of selective electrodes membrane based on complexation of drug with Phosphomolybdic acid (PM) as an active material and using Tributylphosphate (TBP) or Nitro benzene (NB)as a plasticizers , polyvinylchloride (PVC) was used as a matrix for these electrodes . The characters of each electrode were as follow : 1. For electrode METO-PM using TBP as a plasticizer, the results were : 10-5 – 10-1, 18.2 mV/decade ,0.9938 , 1.97 x 10-7 M, and 2.5 – 3 at 25-30oC for linear range, slope , correlation coefficient , limit of detection, and optimum pH range and temperature respectively using internal filling solution of 10-3 M. The life time of the electrode was 26 days . 2. For electrode METO-PM using NB as a plasticizer, the results were : 10-5 – 10-1, 18.9 mV/decade ,0.9975 , 1.83 x 10-7 M, and 2.7 – 3.2 at 25-30oC for linear range, slope , correlation coefficient , limit of detection, and optimum pH range and temperature respectively using internal filling solution of 10-3 M. The life time of the electrode was32 days . Spectrophotometric Method : The drug METO was determined by oxidative coupling reaction using 1 ml of 0.01M sodium periodate and 1.5 ml of the promethazine reagent (1000 μg.ml-1) , the absorption of the colored product is measured at 413 nm. .The molar absorptivity was 6873.42 L.mole-1.cm-1 and Sandel index 0.05154 μg.cm-2 . These methods were successfully applied for the determination of (METO) in Metoclopramide comprimes BP pharmaceutical preparations with recovery of not less than 97 % for the linear concentration range of 5 – 50 μg.ml-1. | ||
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