Study the effect of Insulin Resistance on visfatin, Total Anti oxidant Capacity and other Anti oxidants in Females with Chronic renal Failure [Stage 3]

Awad Mehde, Atheer

	Study the effect of Insulin Resistance on visfatin, Total Anti oxidant Capacity and other Anti oxidants in Females with Chronic renal Failure [Stage 3]
Al-Mustansiriyah Journal of Science
Article 1, Volume 23, Issue 6, 2012, Pages 61-74
Author
Atheer Awad Mehde
Abstract
Chronic Renal Failure (CRF) is the state which results from a permanent and usually progressive reduction in renal function, in a sufficient degree to have adverse con-sequences on other systems .Visfatin is novel adipocytokine that have recently generated much interest. Agreater degree of insulin resistance may predispose to renal injury by worsening renal hemodynamics through the elevation of glomerular filtration fraction. However, there are sparse data on the relationship between Visfatin, insulin resistance with Total Anti oxidant Capacity and other Anti oxidants in chronic renal failure (CRF) [Stage 3].The glomerular filtration rate (GFR)has been measured in 50 patients with CRF using haemodialysis method. Laboratory investigations including Hemoglobin, fasting serum glucose , serum urea, creatinine, S. potassium, S. Sodium S. calcium, S. Phosphorus ,and Uric acid, in addition to serum total antioxidant capacity(TAC), malondialdehyde(MDA)) , vitamin C, vitamin E, Visfatin, insulin and insulin resistance [HOMA] had been measured in female with CRF. Blood samples were obtained from the patients and twenty five healthy individuals who came to the hospital for health checkup.Hemoglobin, fasting serum glucose, Serum urea , S.creatinine, GFR, S. calcium, S.potassium , S.uric acid, TAC,MDA, vitamin C, vitamin E and MDA/TAC ratio showed a significant difference between the female with CRF and control group. Visfatin, insulin and insulin resistance [HOMA] significantly increased [p<0.001]in patients group .There was a positive correlation in Visfatin [ng/ml] with GFR , Hb , insulin, and HOMA. In this study a different significantly association was observed between Visfatin, insulin and Homostasis model assessment [HOMA] with TAC,MDA, vitamin C, vitamin E and MDA/TAC ratio in the CRF patients when compared to control group. In conclusion Visfatin, insulin , HOMA and MDA/TAC ratio levels may be play an important role in complication of disease in patients, As our knowledge, these results in the present study are shown the first time.The study may be useful in designing clinical studies that target utilizing antioxidant systems to provide protective pathways on the pathogenesis of chronic renal failure. Keywords: Insulin resistance, Total Anti oxidant Capacity , Anti oxidants , MDA/TAC ratio, glomerular filtration rate, Chronic kidney disease

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