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The protective role of grape seeds oil on damage induced by iron overload on Liver in male rabbite | ||
| journal of kerbala university | ||
| Article 1, Volume 1, Issue 0, 2005, Pages 180-191 PDF (0 K) | ||
| Abstract | ||
| This study was carried out to investigate the protective role of black grape seeds oil Vitisviniferaon Liver damage induced by iron overload in male rabbits . Twenty five adult male rabbits were divided into five groups (5/group) , the first group was injected with 20 ml/kg normal saline and served as control group (G1) . Rabbits in the second group were injected with 20 ml/kg iron dextran with one dose in the first week , two in the second week , three in the third week and four dose in the fourth week (G2). Rabbits in the third group (G3) were inject with 20 mg/kg iron dextran and intubated orally and daily with ED50 of black grape seeds oil which equal to 0.5 ml/kg, while the rabbits in the fourth group (G4) were injected 20 mg/kg iron dextran with SC injection 10 mg/kg desferrioxamine at one dose in the first week , two in the second week , three in the third week and four dose in the fourth week for each one . Rabbits of the last group were injected 20 mg/kg iron dextran, 10 mg/kg desferrioxamine and 0.5 ml/kg black seeds oil. Fasting blood samples were collected at pretreated , after two weeks and at the end of experiment to study the following parameters : the concentration of Total Cholesterol (TC) , Triacylglycerol (TAG) , High Density Lipoprotin (HDL) , Low Density Lipoprotin (LDL) and Very Low Density Lipoprotin (VLDL) . The results revealed intramuscular injection of iron dextran caused significant decrease (p<0.05) in concentration of High Density Lipoprotin (HDL) ,and significant increase (p<0.05) in concentration of Total Cholesterol (TC) and Low Density Lipoprotin (LDL) While no significant differences was observed in concentration of Triacylglycerol (TAG) and Very Low Density Lipoprotin (VLDL) Comparative with control group . The group that treated with black grape seeds oil and exposure to iron overload by iron dextran revealed no significant difference in the concentration of TC , TAG , HDL , LDL and VLDL . The group that was exposed to injection with desferrioxamine revealed significant decrease (p<0.05) in the concentration of HDL and significant increase (p<0.05) in concentrations of LDL , While no significant differences was observed in the concentration of TC ,TAG and VLDL Comparative with control group . Histological section revealed that iron overload caused deposits of iron as Hemosiderin liver and damage of Liver cells , while the results showed absent deposits of Hemosiderin in the liver as well as normal feature of Liver cells comparative with control group. In conclusion , results of this study confirm the protective role of black grape seeds oil against deleterious effect of iron overload in Liver , and documented the prevalence of black grape seeds oil up on desferrioxamine | ||
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