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Accelerated Stability Evaluation of Captopril Tablets | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 23, Issue 7, 2012, Pages 91-98 | ||
| Author | ||
| Hayder Hamed Abed | ||
| Abstract | ||
| Captopril is one of the most important drugs used to control high blood pressure and help in the relief of chronic heart failure. It may have an effect on reduction of left atrial size in mild to moderate hypertension and on insulin receptor (tyrosine kinase) activity in essential hypertension. Three different batches of Iraqi manufactured captopril tablets were investigated in this research for stability condition. The collected data of assays represent non significant (p>0.05) changes during the storage period with no changes in physico- chemical properties ( color, weight variation, hardness, disintegration, and dissolution). The shelf life of tablets were calculated using Arrhernues equation. The estimation of product shelf life predicted three years validity at room temperature storage. The study concluded that the used formula in manufactured tablets were very stable for three year of date of manufacturing and very suitable for mass production. The applied stability method was very useful in providing information about the stability of manufactured tablets and provides an efficient investigation for mass production. Key word : captopril, accelerated stability study, Arrhenues equation. | ||
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