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Synthesis of Some Heterocyclic Compounds Derived from 1,3-dihydro-2H-indol-2-one | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 2, 2011, Pages 71-78 | ||
| Author | ||
| Nahida A. jinzeel | ||
| Abstract | ||
| In this work (2-oxo-2,3-dihydro-1H-indol-1-yl)Acetic acid was prepared from (1,3-dihydro-2H-indol-2-one) with chloro acetic acid(1). Treatment of (1) with o-Phenylenediamine gave 1-(4,5-dihydro-1H-imidazole-2-yl-methyl)-1,3-dihydro-2H-indol-2-one(2). Treatment of (1) with thionyl chloride gave(3) compound(4) was prepared from (3) with hydrazine hydrate.Reaction of(4)with sccinic anhydride gave 1-[(2-oxo-2,3-dihydro -1H-indol-1-yl) acetyl]tetrahydro pyridazine-3,6-dione(6). Reaction of (4) with sodium nitrate in acetic acid gave (2-oxo-2,3-dihydro-1H-indol-1-yl)acetyl azide(5).Reaction of (4) with phenyl iso thyo cyanate and NaOH offorded 1-[(5-mercapto-4-phenyl-4,5-dihydro-1H-1,2,4-triazole -3- yl)methyl]1,3-dihydro-2H-indol-2-one(8).Azomethene(9-11) were prepared through condensation of (4) with aromatic aldehydes then compounds (9-11) are converted into a number of oxadiazol derivatives(12-14).The structures of these compounds were characterized from their melting point, FTIR,UV-visible spectroscopy, elemental analysis, and NMR. | ||
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