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Synthesis of Dithiocarbamate Derivatives of ((nitrophenyl) diazenyl)-1, 3, 4 thiadiazole as Possible Anticancer Agent | ||
| Al-Mustansiriyah Journal of Science | ||
| Article 1, Volume 22, Issue 2, 2011, Pages 79-88 | ||
| Author | ||
| Azhar Mahdi Jasim | ||
| Abstract | ||
| A physiological feature of many tumor tissues and cells is the tendency to accumulate high concentrations of certain substances, such as copper . While the precise role of copper in tumors is cryptic, copper is required for angiogenesis. Recently reported that organic copper-containing compounds comprise a novel class of proteasome inhibitors and tumor cell apoptosis inducers. In the current study three compounds (IV),(VI) and(VII) designed and synthesized to selectively targeted the cancer cell characterized by elevated level of copper. The generation of the target compounds(IV),(VI) and(VII) were accomplished following multi step reaction procedures. The reaction and purity of the products were checked by TLC, the structure of the final compounds and their intermediates were confirmed by their melting points (uncorrected), infra red spectroscopy. | ||
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