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Anew colorimetric method for the determination of Levo-dopa in pharmaceutical preparation via oxidative coupling organic reaction | ||
| journal of kerbala university | ||
| Article 1, Volume 1, Issue 0, 2005, Pages 7-14 PDF (0 K) | ||
| Authors | ||
| Alaa . F . Hussein; Muneer . A .AL-Da; ; Muhammad .H . AL-Fatlawy | ||
| Abstract | ||
| A simple, accurate and sensitive colorimetric method for the determination of L-Dopa in pure and pharmaceutical preparations has been developed .The proposed method uses ortho–Tolidine as a chromogenic reagent . The method is based on the oxidative coupling reaction of L-Dopa with ortho–Tolidine with potassium periodate in neutral media to form a green–bluish water soluble dye product , that has a maximum absorption at 629 nm . Linear calibration graph was in the range of (0.10 - 28) µg.ml-1 with molar absorptivity of (2.76 ×104 L.mol-1.cm-1) ,a sandall sensitivity of (7.14 ×10-6 µg.cm-2) , correlation coefficient of 0.9997 , detection limit (0.05 µg.ml-1) and the relative standard deviation of RSD% (1.87) . The method was applied successfully for the determination of L-Dopa in pharmaceutical preparations and the value of recovery % was from (99.6%) . | ||
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