Study the Relationship of Toxoplasma IgG Titer with Some Other Immunoglobulin and Complement Components

Abbas Abood Al-Samarrae, Ekram

	Study the Relationship of Toxoplasma IgG Titer with Some Other Immunoglobulin and Complement Components
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 23, Issue 2, 2010, Pages 127-129
Author
Ekram Abbas Abood Al-Samarrae
Abstract
Abstract: Background: Toxoplasmosis is caused by intracellular protozoan parasite; it is difficult to distinguish between the recently acquired infection and the chronic infection because of the frequent presence of Toxoplasma antibodies in the general population. Objective: This study was conducted to estimate the relationship between the Toxoplasma antibodies titers and other immunoglobulin and complement components Study design: Sera from 40 Iraqi blood donors of different ages (18-45 years) during first of February- first of December /2008 in Baghdad city, were screened for Toxoplasma antibodies titers (28 positive and 12 negative). Agglutination method was used according to the kit procedure (Toxo Cell Latex) and single radial immunodiffusion plates were used for estimation of IgM, IgA, C3 & C4. Results: The results showed a significant differences (P<0.01) in the all means of IgM in all titers compared to controls, and the highest titer of IgM (197±21.27 mg/dl) has been shown at a titer of IgG 160 IU/ml. There was no significant differences (P>0.05) shown between IgA titers compared with IgG titers, while there were a high significant differences (P<0.01) of C3 & C4 compared with the IgG titers at level 10, 20&10 IU/ml respectively. Conclusion: The results indicated that there is a relationship between titers of IgG and titers of IgM and complement components (C3 & C4) during the course of Toxoplasma infection especially at the beginning and chronic infection when the level at IgG titers was low. Key wards: Toxoplasmosis, IgG, IgM, C3, C4
Keywords
toxoplasmosis; IgG; IgM

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