Production of Different Cytokines in Acute and Chronic Hepatitis C Virus.

A. Al-Khazraji, Khalid; Sh. Al- Obeidy, Eman

	Production of Different Cytokines in Acute and Chronic Hepatitis C Virus.
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 23, Issue 2, 2010, Pages 134-140
Authors
Khalid A. Al-Khazraji; Eman Sh. Al- Obeidy
Abstract
Summary: Background: the role of pro-inflammatory cytokines has been documented in acute phase reactions in the liver, in normal proliferation of hepatocytes, in autoactivation of Kupffer cells and proliferation of immunocyte, in cirrhotic processes in the liver and in regeneration of the organ in chronic hepatitis C. Objective: assess whether there is a differential production of Th1 or Th2 associated cytokines in the course of acute and chronic HCV infection. Patients & methods: Serum level of IL2, INF gamma (Th1 associated cytokines) and IL10 (Th2 associated cytokines) were measured in 12 patients with acute HCV, 50 patients with chronic HCV infection and 50 healthy volunteers. Results: mean serum level of IL-2 was significantly higher in chronic hepatitis C (30.5 ± 16.02) than in acute cases (26.9 ± 13.01) and controls (11.3 ± 2.03). Acute HCV cases had a higher mean IL-10 level (99.3 ± 17.0) than controls (5.0 ± 2.0) and chronic HCV cases had a higher mean IL-10 level (100.9 ± 53.7) than acute HCV cases. Mean serum level of INF gamma where nearly equal in all three groups. Conclusion: this study suggests weak response of Th1 cells in acute HCV infection and a possible suppressive Th2 cell response in chronic HCV, which might explain the failure of viral clearance and a weak cellular immune response. Key wards: Chronic hepatitis-C; Pro-inflammatory cytokines; IL-2; IL-10 NF-gamma.
Keywords
Chronic hepatitis; Pro; inflammatory cytokines; gamma

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