Relationship between Insulin Resistance, Obesity and Lipid Profile in Diabetic Women with Polycystic Ovarian Syndromes (POS)

Thair Tahir Al-Khalidy, Noor

	Relationship between Insulin Resistance, Obesity and Lipid Profile in Diabetic Women with Polycystic Ovarian Syndromes (POS)
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 23, Issue 4, 2010, Pages 247-250
Author
Noor Thair Tahir Al-Khalidy
Abstract
Abstract: Background: Polycystic Ovary Syndrome is not only a reproductive endocrinopathy but also a metabolic disorder, diabetes; dyslipidemia and obesity are all potent cardiovascular risk factors that tend to cluster in women with Polycystic Ovary Syndrome. Metabolic disorders in patients with Polycystic Ovary Syndrome can not be explained solely by the presence of obesity. Objective: This study was designed to uncover the relationship of insulin resistance, obesity and lipid profile in diabetic women with polycystic ovary syndrome. Patients & Methods: This study included 65 Polycystic Ovary Syndrome women with insulin resistance type 2 diabetes aged between (20-55) years who were attending the National Diabetes Center / AL- Mustansiriya University .The enrolled patients were divided according to their body mass Index (BMI) into three groups ; normal (BMI<25 kg/m2) ,over weight (BMI= 25-30 kg/m2) and obese (BMI> 30 kg/m2) ;and estimated waist hip ratio as well .Venous blood samples from women were taken for laboratory investigation which included : Fasting plasma Glucose , Glycated Hemoglobin , lipid profile (triglyceride ,total cholesterol ,high density lipoprotein and low density lipoprotein) ,Fasting Insulin levels and Homeostasis Model Assessment Insulin Resistance( HOMAIR) ;and abdominal ultra sound examination was conducted for all . Results: The diagnosis of type 2 diabetic polycystic ovary was established in 65 women of different age: In this study HOMA test revealed marked reduction (increased insulin resistance) in type2 diabetic Polycystic Ovary Syndrome women. Normal weight showed high percent (46.1%) compared with overweight and obese in Polycystic Ovary Syndrome diabetic women .Fasting plasma glucose and glycated hemoglobin was shown significantly higher in obese diabetic Polycystic Ovary Syndrome women ,fasting serum insulin was significantly increase in non obese. Fasting plasma glucose and glycated hemoglobin level shows strong positive correlation of all lipid profile (triglyceride, total cholesterol, high density lipoprotein and low density lipoprotein) in diabetic Polycystic Ovary Syndrome women .HOMAIR shows there was a highly significant positive correlation with total cholesterol and triglyceride while low significant with high density lipoprotein and there was insignificant correlation between low density lipoprotein and Insulin resistance. Insulin level shows positive correlation with (triglyceride, total cholesterol, high density lipoprotein) and no significant with low density lipoprotein in diabetic polycystic ovary women. Conclusion: Insulin resistance among polycystic ovary syndrome diabetic women was very evident and has strong correlation with lipid profile elements, while there is no such correlation obesity. Keywords: Insulin resistance, type 2 diabetic PCOS women, obesity, lipid profile.
Keywords
Insulin resistance; Type; Obesity; Lipid profile

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