Biological activity of 5-benzylidene thiobarbituric acid derivative against some bacteria isolated from burns infections

Jasim Al-Shamarti, Mohammed; Hassoon Mageed, Ahmed; Idaan Mushin, Muslim

	Biological activity of 5-benzylidene thiobarbituric acid derivative against some bacteria isolated from burns infections
Al-Qadisiah Medical Journal
Article 1, Volume 8, Issue 2, 2012, Pages 50-62 PDF (0 K)
Authors
Mohammed Jasim Al-Shamarti; Ahmed Hassoon Mageed; Muslim Idaan Mushin
Abstract
A total of fifty (50) samples were collected from burn infections from AL-Sader Medical City in Alnajaf Alashraf during the period from the 24th of January to the 4th of April . Different percentages of different bacteria were noted as follows , Pseudomonas aeruginosa was the highest percentage about 33% followed by Ps. florescence 8( 16 %) , both E.coli & Klebsiella Sp comprised 6 (12%) ,and Aeromonas sp was the lowest ratio comprising 2% . The most bacteria appeared resistance to antibiotics, Pseudomonas aeruginosa was found to be resistant to most of the therapeutic agents. In this paper a synthesis of 5-benzylidene thiobarbituric acid derivative have been described. The route of preparation involved the uses of thiobarbituric acid as starting material and treated with 4-dimethylaminobenzaldehyde compound to give required derivative this compound have been identified by a spectroscopic method like H-NMR, IR and CHNS analysis and also by measuring its melting point.A simple synthetic route for 5-(4-dimethylaminobenzylidene)thiobarbituric acid by the condensation reaction of 4-dimethylaminobenzaldehyde with thiobarbituric acid in water without catalyst is described. The results revealed that proteus sp. was affected by chemical model more than the other bacteria , increasing the concentration of the compound increases the inhibition zone .also bacteria Klebseilla sp. Pseudomonas aeruginosa. affected by compound model ,but bacteria Staphylococcus arueus was not affected by any concentration of compound. The aim of of this study was to determine the model of chemical compounds effect on the growth of some bacteria isolated from buruns in vitro.

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