Non-hormonal treatment for mastalgia-a topical non-steroidal anti-inflammatory agent versus Evening Primrose Oil:  prospective comparative analysis

Kamil Mohammed, Mohammed

	Non-hormonal treatment for mastalgia-a topical non-steroidal anti-inflammatory agent versus Evening Primrose Oil: prospective comparative analysis
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 23, Issue 4, 2010, Pages 282-286
Author
Mohammed Kamil Mohammed
Abstract
Abstract: Aim of the study: to compare a topical non-steroidal anti-inflammatory drug (NSAID) and Evening Primrose Oil (EPO) regarding effectiveness, rapidity of response, safety, and patient compliance in the primary treatment of mastalgia. Setting: Author’s Private clinic** Design: A prospective interventional non-blinded comparative clinical trial between the two drugs carried out over a period of 4 years. Patients & Methods: seventy female patients with moderate to severe mastalgia were prospectively selected and given one of the two agents alternatively. Data pertaining to each patient were collected and analyzed at one month, two months and three months period. Results: after three months of treatment, out of 35 patients treated with topical NSAI gel, 96.5% had clinically significant response compared with 45.7% of 35 patients treated with EPO. Two patients (5.7%) had side effects with EPO treatment while none had any side effects with NSAI gel treatment. Response to NSAI gel reported earlier than response to EPO. 82.8% of patients found the cost of NSAI gel treatment acceptable versus 85.7% for EPO. Conclusions: Topical NSAIDs are effective, safe and acceptable mode of treatment for mastalgia. Keywords: Mastalgia. Evening Primrose Oil (EPO). Topical NSAIDs.
Keywords
Mastalgia; Evening Primrose Oil; Topical NSAIDs

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