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The Role of Thyrotropin Hormone Receptor Antibody (TRAb) in Distinguishing between Autoimmune and non-Autoimmune Disease | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 10, Issue 1, 2013, Pages 153-161 | ||
| Authors | ||
| Saif Ali Muttaleb; Muhanned Abbas Al-shalah; Moaed Emran Al-Gazally | ||
| Abstract | ||
| The present study was intended to investigate Thyrotropin Receptor Antibody (TRAb) level in hyperthyroidism. A total of 65 patients and 25 apparently healthy as a controls were assessed. Twenty-seven of the 65 patients had Graves' disease, twenty-one had toxic nodular goitre and the remaining group had toxic nodule. In comparison with the control group, patients with diffuse goitre showed a highly significant increase in TRAb (P<0.01) significant increase in TRAb (p < 0.05) in nodular toxic goitre, while non-significant (p> 0.05) found in nodule toxic. Thyroid function tests appear significant increase (P<0.01) T4, T3 while significant decrease in thyroid stimulating hormone TSH concentrations. The incidence of positive TRAb assay in diffuse goitre group was 89%, whereas 24% were positive in toxic nodular goitre group and 6% in toxic nodule. It can be concluded that as a practical method, TRAb assay may be useful in making a differential diagnosis of Graves' disease rather than other autoimmune thyroid diseases (toxic nodular and toxic nodule). | ||
| Keywords | ||
| Thyrotropin hormone receptor antibody; Toxic multinodular TMN; Toxic nodule | ||
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