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Lipid profile and Arterial Walls Properties in Hypothyroidism | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 19, Issue 1, 2006, Pages 87-91 | ||
| Author | ||
| Riadh Abdul Razzaq Al- Rammadani | ||
| Abstract | ||
| Abstract: Background: The link between lipid profile and ischemic heart disease was known long ago but more recently this link has been extended to include blood clotting factors. Objective: Because hypothyroidism was considered as an example of atherosclerosis. The aim of this study is to investigate the relation between atherosclerosis in hypothyroidism and lipid profile, factor VII, von Willebrand factor, and finally common carotid artery distensibility. Methods: Plasma lipid profile including: total cholesterol (TC), triglyceride (TG), high density lipoprotein(HDL), low density lipoprotein (LDL) and oxidized low density lipoprotein (OXLDL), in addition to that factor VII and von Willebrand factor studied biochemically, while common carotid artery distensibility coefficient (CCADC) studied ultrasonographically in group I ( euthyroid subjects) and group II (hypothyroid subjects). Results: The present study showed an increase in all biochemical markers excepted for HDL who has decreased in addition to the decrease in CCADC in group II as compared to group I. Changes in lipid profile was blamed to be the cause behind atherosclerotic changes in hypothyroidism, while increased triglyceride may play a role in the increase in factor VII. The increase in plasma cholesterol, LDL and OXLDL linked with the increase in von Willebrand factor. However, atherosclerotic arterial wall was the possible extra-hepatic source of the above factors in hypothyroidism. The CCADC decreased could be due to increase in LDL or OXLDL. Conclusion: both factors VII and von Willebrand could play a role in atherosclerotic changes in hypothyroidism which could be evaluated by CCADS. Key words: Hypothyroidism, Factor VII, Von Willebrand Factor, lipid profile, common carotid artery distensibility coefficient | ||
| Keywords | ||
| Hypothyroidism; Factor VII; Von Willebrand Factor; Lipid profile; common carotid artery distensibility coefficient | ||
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