Antioxidants Use of Vitamin C and vitamin E in Patients with Vitiligo

M. Al-Hilo, Maytham; K. Ahmed, Wedad; E. Sharquie, Khalifa; A. Hamadi, Salim

	Antioxidants Use of Vitamin C and vitamin E in Patients with Vitiligo
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 19, Issue 2, 2006, Pages 118-125
Authors
Maytham M. Al-Hilo; Wedad K. Ahmed; Khalifa E. Sharquie; Salim A. Hamadi
Abstract
Abstract: Background: The etiology of vitiligo is still unknown, but the autocytotoxic theory suggests that increased melanocytes activity leads to its own destruction. One of the proposed mechanisms by which autocytotoxicity may occur is that the destruction take place through reactive oxygen species. Objectives: The present work was arranged to evaluate the effect of antioxidants in the form of vitamin C and vitamin E in patients with vitiligo in the view of their effects on the alterations in oxidative stress as measured by plasma and red blood cells Malondialdehyde (MDA) and the changes in antioxidant mechanism as measured by plasma and red blood cells Glutathione (GSH).. Patients & Methods: Twenty-three patients with vitiligo were included in this study. The severity of the disease was graded according to the rule of nine into three grades (mild, moderate, and severe). The oxidative stress (plasma and red blood cells Malondialdehyde) and the antioxidants (plasma and red blood cells Glutathione) were measured in all patients. All patients included in this study received a combination of vitamin C and E (vitamin C 500 mg, vitamin E 100 mg twice a day) for 2 weeks and then the oxidative stress (plasma and red blood cells Malondialdehyde) and the antioxidants (plasma and red blood cells Glutathione) were measured again. Results: The results showed that only the mild group showed a statistically significant reduction in mean plasma MDA of 0.86 micro mole/L after two weeks of treatment P<0.02. The changes observed in mean plasma MDA in the remaining 2 groups and in the total cases were small and not statistically significant, while in erythrocytes MDA, the changes observed in mean erythrocytes MDA in the 3 severity groups of vitiligo and in the total cases were small in magnitude and not significant statistically. Also, the changes observed in mean Plasma GSH in the 3 severity groups of vitiligo and in the total cases were small in magnitude and not statistically significant. Conclusion: The results showed that the oxidative stress decreased significantly after treatment with antioxidant drugs in the mild group (i.e. early in the course of the disease when the disease is still active) and this may have a therapeutic applications suggesting that antioxidants may help to decrease the oxidative stress if it was given early in the course of the disease. Keywords: Vitiligo, Glutathione, Malondialdehyde, Antioxidants, Oxidative stress.
Keywords
Vitiligo; Glutathione; Malondialdehyde; Antioxidants; oxidative stress

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