Study of Ciprofloxacin Resistant Escherichia coli (CREC) in Type 2 Diabetic Patients with Symptomatic Urinary Tract Infections

Yousif Abdul-Sahib, Kadhum

	Study of Ciprofloxacin Resistant Escherichia coli (CREC) in Type 2 Diabetic Patients with Symptomatic Urinary Tract Infections
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 21, Issue 1, 2008, Pages 55-60
Author
Kadhum Yousif Abdul-Sahib
Abstract
Abstract: Background: Type 2 diabetes is the most common form of diabetes among diabetic population. Escherichia coli (E. coli) remain the predominant uropathogen in diabetics and this pathogen is traditionally associated with urinary tract infections (UTIs) and it has a high resistance for antibiotics. The risk factors for CREC isolates were included: prior ciprofloxacin use, other quinolone use, self catheterization and recurrent UTI. Objectives: To determine the prevalence of CREC in type 2 diabetic patients with symptomatic UTI, and the prevalence of bacterial infections among those patients. Patients and Methods: The present study included 100 type 2 diabetic patients with symptomatic (UTIs) attended the National Diabetes Center (NDC) of Al-Mustansiria University, and 20 with age matched non-diabetic patients with symptomatic(UTIs) association with E. coli. Data regarding age, sex, plasma glucose (Random or Fasting) and urine samples for direct examination and cultures were investigated. Serum levels of glucose were determined by using auto-analyzer system (Abbott). The diagnosis of bacteria isolates and their in vitro susceptibility to antibiotics were evaluated by Kirby Bauer method. Results: Out of 100 diabetic patients with symptomatic UTI, 50 patients had positive growth culture, of those 34 patients had pathogenic E. coli. The percentage of ciprofloxacin resistant E. coli was 70.6%. There was a significant difference between the diabetic patients with ciprofloxacin resistant E. coli and control group (P< 0.01). Conclusions: High resistant activity of E. coli to ciprofloxacin was recorded in this study among diabetic group compared to non-diabetic group. The increase in ciprofloxacin resistance might be attributed to the diabetes associated with UTI and considering diabetes as one of the risk factor. Key words: Type 2 diabetes, Urinary tract infections, ciprofloxacin resistance and E coli
Keywords
Type; Urinary tract infections; ciprofloxacin resistance and E coli

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