The constitution of the Family in Childhood Leukemia

Ani,; H. Abdullah Al, Mouroge

	The constitution of the Family in Childhood Leukemia
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 21, Issue 1, 2008, Pages 79-83
Authors
; Mouroge H. Abdullah Al
Abstract
Abstract Background: There is evidence that leukemia in general is higher among children whose mothers had previous abortions, knowing that there are many other factors which participate in increasing incidence of leukemia among certain families. Objective: To find out the relationship between the consanguineous marriage and the history of family cancer with the number of maternal abortions and the birth order of the leukemic child. Patient & Method: one hundred twenty children with acute leukemia and 150 children as a control attending out patient clinic in Central teaching Hospital for Children for the period 1st Dec 2002- 1st May2003 were randomly selected . Questionnaire about family history of any type of cancer, number of maternal fetal loss, birth order of the leukemic child and the consanguinity between the parents in both patients and control had been obtained Results: Forty three (43%) of acute leukemia in this study have positive consanguineous marriage while the control group is (40%). For maternal history of abortions 33.3% of the leukemic mothers had history of abortion (28 mother had one abortion, 3mother had 2 abortion, 7 had 3 abortion, and2 more than 3), while in the control there is 30%. Family history of cancer is positive in 25 (20.8%) family of leukemic children and as such,11 leukemia,1 lymphoma, 3 CA breast, 1 brain tumor ,3renal , 1 uterine, and 5 unknown. While family history of malignancy among control group is 22 (14.3%) and most of them were of solid tumor like CA stomach, larynx, prostate. Children after 1st child and before the last one had higher incidence of leukemia in the family setting and constitute 61.6%. Conclusion: Family history of cancer was statically higher in leukemic families with more incidence of leukemia than in the control group. Regarding history of no. of abortion there is no significance difference. Being of consanguineous marriage there is no significant difference from the control knowing that there is frequent consanguineous marriage among Iraqi people. Birth order seems to involve those follow 1st child and before last one. This explains the viral theory and other postnatal genetic alteration behind etiology of leukemia. Key wards: acute leukemia, risk factors, children.
Keywords
acute leukemia; risk factors; Children

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