The Effects of Some New Macrolides on Psychomotor Performance in Humans.

M. S. AL- Mashhadani, Waleed

	The Effects of Some New Macrolides on Psychomotor Performance in Humans.
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 19, Issue 2, 2006, Pages 172-177
Author
Waleed M. S. AL- Mashhadani
Abstract
Abstract: Objective. The study was designed to show the effects of single oral doses of new macrolides (Clarithromycin, Roxithromycin and Azithromycin) on psychomotor performance by using the computerized Leeds psychomotor Tester... Setting: Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad- Iraq. Design: double-blind, balanced and controlled study. Main outcome measures: Choice reaction time (CRT), recognition reaction time (RRT) movement reaction time (MRT), and critical flicker fusion Frequency (CFF). These parameters were recorded before treatment and 2 hours interval taking 2 readings post treatment Results: The results showed that the changes in the CRT,RRT ,MRT and CFF values following the three new macrolides treatments ,not significantly different between the four treated groups , nor across the two hours intervals of the study. Conclusion: Single oral doses of the new macrolides Clarithromycin (500 mg) Roxithromycin (150 mg) and Azithromycin (250 mg)have no impairment effects on the sensorimotor and arousal states in . These findings increase the safely profile of the new macrolides. Key wards: Macrolides, Psychomotor Performance, Clarithromycin, Azithromycin, Roxithromycin
Keywords
Macrolides; Psychomotor Performance; Clarithromycin; Azithromycin; Roxithromycin

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