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Rate of GAD Antibodies in First Degree Relatives of Type 1 Diabetes Mellitus | ||
| IRAQI JOURNALOF COMMUNITY MEDICINE | ||
| Article 1, Volume 19, Issue 3, 2006, Pages 228-230 | ||
| Author | ||
| Husham Raheem Amaarij Al-Eedanie | ||
| Abstract | ||
| Abstract Background: Attempts to identify the earliest events in the auto-immune affection of first degree relative (siblings) of Type 1 DM, glutamic acid decarboylase (GAD) is one of the most important auto antigens. Objective: To detect the prevalence of GAD antibodies in first degree relative of Type 1 DM. Patients & Methods: Sera were obtained from 53 normal siblings (26 male and 27 female) mean age 11.5 4.8 years. Sera were analyzed for GAD using the enzyme linked immunosorbent (ELISA) technique. Results: Prevalence of GAD antibodies was 7.5% and impaired GTT in 75% of individuals with pathological GAD values. Conclusion: Iraqi children and adult have prevalence rates of anti GAD antibodies among siblings of type1 DM which is so high and anti-GAD may be valuable as an early predictive marker for type 1 DM. Key words: Glutamic acid decarboxylase type 1 diabetes mellitus | ||
| Keywords | ||
| Glutamic acid decarboxylase type | ||
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