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Synthesis, Characterization and Cytotoxic Activity of Some Pyrimidine Derivatives | ||
| Journal of Al-Nahrain University - Science | ||
| Article 1, Volume 16, Issue 2, 2013, Pages 84-92 | ||
| Authors | ||
| Salman Ali Ahmed; Tamara Sami Naji; Farooq Ibrahem Mohammad | ||
| Abstract | ||
| Synthesis of some pyrimidine derivatives which plays an important role in the medicinal chemistry because it possesses promising cytotoxic activity. The synthesized compounds were characterized by UV-Visible and FT-IR spectral data. Some of the new compounds were evaluated for their potential cytotoxicity against two different human cancer cell lines HepG2 (hepatocellular carcinoma) and MCF-7 (breast adenocarcinoma) in vitro, using Neutral Red and MTT assays. The synthesized compounds were active against two cell lines under study and a toxic effect was clear with a significant difference at the level of probability (p< 0.0001) and this effect was contrasted among different concentrations for each synthesized compound. | ||
| Keywords | ||
| Pyrimidine derivatives; Cytotoxic activity; Human cancer cell lines | ||
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