Assessment of P53 and soluble FasL (sFasL) serum concentration  in females with benign & malignant breast tumors

O. Yousif, Sura; Shakir Mahmood, Aqeel; A. AL- Haidary, Batool

	Assessment of P53 and soluble FasL (sFasL) serum concentration in females with benign & malignant breast tumors
IRAQI JOURNALOF COMMUNITY MEDICINE
Article 1, Volume 26, Issue 2, 2013, Pages 124-128
Authors
Sura O. Yousif; Aqeel Shakir Mahmood; Batool A. AL- Haidary
Abstract
Abstract Background: During Embryonal development and morphogenesis apoptosis may be induced by two pathways. The first is an external P53 protein signal originating from other cell-also named as death signal another is specific cell reaction to external stress factors. Serum concentration of proteins regulating external pathway may be useful in early diagnosis and staging of breast tumors. Objective: The aim of the study was to evaluate P-53 and sFasL serum concentrations in patients with benign and malignant breast tumors. Methods: The study population was composed of 69 patients [33 patients with newly diagnosed breast carcinoma, 6 patients with recurrent carcinoma and 30 patients with fibroadenoma (tumor types were verified by fine –needle biopsy)], ELISA Technique was applied for estimation of both P-53 & sFasL levels as well as apparently healthy 50 volunteer's women. Results: p53 and sFasL levels were evaluated before surgery. The results revealed high p53 serum concentration in patients with recurrent breast cancer in comparison with other groups which may be considered as a prognostic marker; while, sFasL revealed no significant differences between its levels among the studied groups though it was elevated among benign breast tumor subjects. Conclusion: Estimation of P-53 level showed significantly elevation of the concentration among the sera of recurrent breast cancer in comparison with other groups which may be considered as a prognostic marker. Key words: p53, sFasL, breast cancer.
Keywords
sFasL; Breast Cancer

Statistics Article View: 38 PDF Download: 4