Primary Biliary Cirrhosis  in a Sample of Iraqi Patient

M. Al-Khalidi, Nawal; A.Sayah, Hadi; Jaber, Hamid; Jarallah, Sadiq; M. Al-Maliki, Jassim

	Primary Biliary Cirrhosis in a Sample of Iraqi Patient
Kerbala Journal of Medicine
Article 1, Volume 1, Issue 1, 2007, Pages 110-115 PDF (0 K)
Authors
Nawal M. Al-Khalidi; Hadi A.Sayah; Hamid Jaber; Sadiq Jarallah; Jassim M. Al-Maliki
Abstract
Background: Primary biliary cirrhosis(PBC) is an autoimmune liver disease that generally affects middle aged women and it is the most common chronic cholestatic liver disease in adult .There are a few studies described this disease in Iraq . Aim of the study: The aim of this study is to evaluate a sample of Iraqi patients with primary biliary cirrhosis regarding the clinical presentation, investigations and associated diseases. Setting: Gastroenterology and Hepatology teaching hospital-Baghdad-Iraq Result: Thirty-two patients involved in this study (mean age 45.9 year), most of patients were female .All patients presented with itching, and most of them with jaundice, about two thirds of patients complained of fatiguability and more than half of them had abdominal pain. Eighty–seven percent of patients were younger than 60 years old. Fifty percent of them had serum bilirubin less than 6 mg/dl, 39.3% had serum bilirubin more than 6 mg/dl .One-third of them had prolong prothrombin time, while serum alkaline phosphates is elevated in all patients, and about 80% of patients had elevated liver enzymes .About 75% of patients had positive AMA,while ANA was positive in 21.9% of patients .Liver biopsy was compatible with PBC in 56.3% of patients . Primary biliary cirrhosis associated with many diseases .In this study 28.1% of patients had PBC associated with arthralgia, Sicca syndrome found in 12.5% of patients, 6.3% had full-blown picture of scleroderma, thyroid disease mentioned in 6.3 % of patients .Gall bladder stones reported in 9.4 % of patients.

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