The Effect of High Insulin Resistance and Obesity on serum level of IL-12 in a sample of Iraqi patients with Type 2 Diabetes Mellitus

S. Al-shawk, Refif

	The Effect of High Insulin Resistance and Obesity on serum level of IL-12 in a sample of Iraqi patients with Type 2 Diabetes Mellitus
Al-Mustansiriyah Journal of Science
Article 1, Volume 24, Issue 2, 2013, Pages 11-20
Author
Refif S. Al-shawk
Abstract
The IL-12 plays a critical role in the pathogenesis of type I and type II diabetes mellitus, but the significance of IL-12 changes in the blood of patients with type 2 diabetes mellitus T2DM remains unclear. However, it is not known whether factors related to the course of T2DM, such as metabolic compensation, beta cell secretary dysfunction, and insulin resistance affect IL-12 concentrations. To determine the serum level of IL-12, in a sample of T2DM obese type 2 diabetic patients. This determination was interpreted on the ground of obesity (body mass index; BMI) and insulin resistance (homeostatic model assessment; HOMA). The study was conducted on 50 type 2 diabetic patients, 29 females and 21 males, the age range within 28-60 years .For the purpose of comparisons, Thirty control subjects comparable to diabetic patients in respect to age (33-59 year) and gender (16 females and 14 males), were included in the study. Fasting plasma glucose, Insulin and serum IL12 was determined to assess Insulin resistance by using HOMA model. Also body mass index was measured. The mean of insulin serum level (12.4 vs. 8.3 µIU/ml) or HOMA (5.5 vs. 1.8) was significantly increased in T2DM patients as compared to controls. The serum level of IL-12, (19.3 vs. 6.0 pg/ml) showed significant (P ≤ 0.001) increase in geometric mean in T2DM patients as compared to controls. IL-12 showed a non-significant variation between the three groups of obesity (normal, overweight and obese). The HOMA had the most important impact on the outcome variable, after adjusting for BMI and study group. An increase in HOMA index was associated with a proportional increase in serum IL-12 and able to explain 26.7% of the observed variation in the outcome variable therefore this cytokine may play a critical role in the pathogenesis and complication of T2DM.

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