Association Of Free Testosterone And Insulin Resistance In Young Men With  A Family History Of Diabetes

Abd Jassim, Najlaa

	Association Of Free Testosterone And Insulin Resistance In Young Men With A Family History Of Diabetes
Al-Mustansiriyah Journal of Science
Article 1, Volume 24, Issue 3, 2013, Pages 21-28
Author
Najlaa Abd Jassim
Abstract
Insulin resistance is associated with metabolic syndrome , type 2 diabetes and representing a risk factor for cardiovascular disease . This relationship may be modulated to some extent by age related changes in sex hormone status. Aim of study: we examined whether free testosterone level were associated with insulin resistance in young adult men. Methods: a total of 83 men (young adult men) divided into 2 group : (group1 ) 49 men with a risk factor for insulin resistance (with a family history of type 2 diabetes and hypertension ) and ( group2) 34 men without risk factor aged (20-40) years. Age, body mass index (BMI) and waist circumference were measured. Early morning were assayed for free testosterone, total testosterone, and insulin levels. insulin resistance was assessed using a homeostatic model (HOMA-IR) also Lipid Profile levels were measured. Results: Free testosterone , declined progressively across increasing quintiles of HOMA-IR as a mean of (20.68±11.10) pg/ml in group1 compared mean (33.40±21.94) pg/ml in group 2 and no significant correlation with HOMA-IR also with insulin in both group . Free testosterone correlated inversely with age (r=-0.415, p=0.015) and positively correlated with total testosterone (r=0.469, p=0.005) in group2 . There is a significant positive correlation between HOMA- IR of group1 and BMI (r= 0.472) (p<0.001),and insulin levels (r=0.698) (p<0.0001) .Conclusions : In young adult men , free testosterone is non significantly associated with insulin resistance.

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